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Estradiols central effects on appetite are also modulated by a number of other peripheral signals ( Figure 1 )
As noted by Manasyan et al., while these agents reduce insulin requirements and maintain adequate glucose control with fewer hypoglycemic events, they may simultaneously impede adequate nutrition as a result of delayed gastric emptying and present a risk of aspiration
Previous studies have shown that gliosis near substantia nigra neurons may contribute to the progression of PD via microglial-mediated injury [68]
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