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Red areas indicate increased cFOS activity and blue areas indicate decreased cFOS activity
The six groups included (i) control group, (ii) stress group, (iii) group with DSIP one hour before stress experiments, (iv) DSIP 24 hours before stress experiments, (v) DSIP one hour before the last stress experiment and (vi) DSIP 24 hours before the last stress experiment
The natural compound T1 isolated from Gastrodia elata shows outstanding inhibitory potency against tyrosinase (IC 50 = 0.53 M, K i = 58 6 nM), which is more effective than -arbutin, kojic acid, short peptides 74,75 and other known natural compounds (Supplementary Table S1)
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