[3] [5] For patients with LDL-C 190 mg/dL, high-intensity statins are first-line therapy, with consideration of ezetimibe, bempedoic acid, or PCSK9 inhibitors for additional lowering
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However, since CHX only partially reduces its protective effect, this mechanism is not strictly required, indicating the existence of additional, protein synthesis-independent pathways
No obstante, tambin advirti de que existen circunstancias en las que no se satisface la demanda orgnica de esta sustancia, por defectos genticos en el sistema de su transporte hacia las clulas o un aporte insuficiente de protenas en la dieta, con la consiguiente deficiencia de lisina y metionina, necesarias para la biosntesis de carnitina