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Following the study period, further analysis of the femur was conducted using mid-diaphyseal peripheral quantitative computed tomography (pQCT) scans

Mechanistic evidence has indicated that GLP-1RAs promote bone marrow-derived macrophage polarization into the M2 phenotype via the cAMP-PKA-signal transducers and activators of the transcription 3 (STAT3) pathway [137, 138]

Ces succs sont encore plus prononcs chez les personnes traites avec le tirzepatide, avec prs de 60 % des patients qui ont perdu 20 % de leur poids et prs de 40 % qui ont mme perdu plus de 25 % de leur poids initial (Figure 6B)

2021 NEJM) to 20.9% (SURMOUNT-1, Jastreboff et al