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The most common side effects are nausea (~15%), diarrhea (~15%), and other gastrointestinal complaints
Furthermore, dual drugs exhibit enhanced binding affinity, suggesting their efficacy in inhibiting Pf GR, where the aliphatic ester bond (linker) is essential for effective binding with the enzymes active site
However, dosing is also titrated slowly usually in 4 to 6 weeks increments
Sex differences and GSH Our sex-stratified analyses revealed that thalamic GSH reduction in migraine was significant and comparable in both males ( = 0.4530.511) and females ( = 0.4040.472)
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