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51,52 By increasing nitric oxide availability, GLP-1 RAs improve endothelial function versus lifestyle intervention alone, an effect demonstrated through the measurement of coronary flow velocity reserve by echocardiographic evaluation after the administration of exenatide
This contradicts the labeling on approved brand-name products (Mounjaro for tirzepatide, Ozempic/Wegovy for semaglutide), which explicitly state not to freeze these medications
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