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Since 2023, Indianapolis-based Lilly has filed lawsuits against dozens of compound pharmacies, weight-loss centers and health spas that produced and sold copies of its Type 2 diabetes treatment Mounjaro and weight-loss treatment Zepbound
Excessive production of ROS, largely arising from mitochondrial oxidative phosphorylation, is a major driver of oxidative damage and mitochondrial dysfunction processes that correlate with MDD symptom severity, illness chronicity, cognitive impairment, and poor antidepressant response [138, 139]
The supplementation must be attentive as the reference ranges of Se blood levels are narrow, and the risk of insufficient or toxic supplementation is possible (245, 246)
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