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MuRF1 primarily targets sarcomeric proteins and forms part of a Cullin4A-DDB1-DCAF8 E3 ligase complex, while Atrogin-1 preferentially degrades regulatory factors such as MyoD1 and eIF3-f

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Bischoff-Ferrari HA, Gngler S, Wieczorek M, Belsky DW, Ryan J, Kressig RW, Sthelin HB, Theiler R, Dawson-Hughes B, Rizzoli R, Vellas B, Rouch L, Guyonnet S, Egli A, Orav EJ, Willett W, Horvath S (2025) Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial

As they are shorter than proteins, they enter the bloodstream more quickly