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VIP delivery challenges The main limitation of VIP as a therapeutic peptide is its extremely short plasma half-life
Three subjects were excluded from all AUC 024h and C max Day 10 analyses: two withdrew from the trial before the 10th dose (one subject in each of the 2 hnight and night30 min treatment arms as described above) and one subject had an incomplete Day 10 pharmacokinetic profile (6 h30 min treatment arm)
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