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In: Feingold KR, Anawalt B, Blackman MR, et al, editors

In addition, higher levels of phosphorylated (active) LKB1 were noted under these conditions in the livers of KO mice but not WT mice (Fig

These users report appreciating treatment benefits while active but watching improvements gradually fade over months post-discontinuation, with timeline showing first 2 months maintaining most benefits creating initial optimism, months 2-4 showing noticeable decline returning toward baseline, months 4-8 continuing regression approaching pre-treatment status, and stabilization occurring 60-80% back toward original baseline with only modest long-term improvement retention