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Beyond the GLP-1 receptor, it also targets the GIP (glucose-dependent insulinotropic polypeptide) receptor

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moreover, mice and humans differ in microbiota, diet, and environmental exposures (e.g., fiber intake, antibiotic history), so translation to ASD children remains speculative

Treatment duration is limited to two years, both because of regulatory guidelines related to an osteosarcoma signal in rat studies (which has not been observed in humans, and the original black box warning has been removed) and because efficacy tends to plateau