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RCD plays a central role in DKD, overactivated TECs apoptosis causes tubular injury, autophagy deficiency disrupts cellular energy recycling and homeostasis, ferroptosis exacerbates mitochondrial injury via lipid peroxidation and iron overloading, and pyroptosis causes overactivated local cascadic inflammatory response to aggravates renal damage (13, 132, 224)

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As further clinical data becomes available, it will help determine how its efficacy compares with currently approved injectable GLP-1 therapies

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