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Liver health also matters, as metabolic processing involves hepatic pathways

doi:10.1053/j.gastro.2006.05.055 71 DubPEBrubakerPL

For instance, in November 2023, results from the SELECT trial published in the New England Journal of Medicine showed that once-weekly semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease without diabetes, highlighting the expanding role of long-acting GLP-1 analogues beyond glycemic control into cardiovascular risk reduction

However, it's important to note that semaglutide is not FDA-approved for the treatment of MASH