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occasionally hard Maybe multifocal, usually when malignant MICROSCOPIC PATHOLOGY Histologic Features Melanotic schwannoma High cellularity, lobules and fascicles Spindle to epithelioid cells Eosinophilic to amphophilic cytoplasm Clear cells occasional Occasional multinucleation Variable pigmentation Nuclear/cytoplasmic pseudoinclusions Pigmentation variable or patchy Thin-walled vessels Scan often incomplete collagenous capsule Palisading, Verocay bodies, microcysts (very uncommon) Melanophages frequent and most pigmented of cells Benign Delicate chromatin and small nucleoli Rare mitoses Malignant Vesicular nuclei and coarse chromatin Stay updated, free articles

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Fragment ion at m/z 226 suggested formation of an additional ketone structure