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However, GLP-1 drugs have surged in popularity due to their ability to support major weight loss and reduce risks for chronic conditions, including heart disease

In DUAL-1 the A1c reduction from baseline with IDegLira was somewhat higher (estimated difference of 0.21%) in patients in use of pioglitazone and metformin compared to those with metformin alone (A1c for IDegLira 1.8% in the metformin subgroup and 2.1% in the metformin plus pioglitazone subgroup

Clinical experience with semaglutide and tirzepatide shows weight typically returns after discontinuation, which supports long-term use

10.1007/s00280-015-2723-x Cancer Chemother