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No randomized trials No controlled studies No validated imaging or outcome measures Only one very small, biased case series 2

Esta sobreexpresin de SLGT2 aumenta el transporte mximo (Tm) para la glucosa a valores 40-60mg/dl ms altos que el umbral fisiolgico de saturacin (glicemia180mg/dl en sujetos sanos a 240mg/dl en DM2) de manera que la glucosuria se inicia a partir de niveles glicmicos ms elevados a los esperados, lo que se traduce en una mayor reabsorcin de glucosa contribuyendo a mantener la hiperglicemia101,102,106

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