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Whether this dose should be maintained for long-term treatment is currently being investigated in the BOND study, which evaluates the effects of 12 months of benfotiamine treatment (300 mg twice daily) on morphometric, neurophysiological and clinical parameters in individuals with T2D and mild-to-moderate symptomatic DPN [73]
AOM prescribing increased in December 2025 compared to September 2025 (+10.1%)
A higher 5-Amino-1MQ dosage might be necessary in subjects with advanced metabolic dysfunction to achieve a noticeable effect
Its effectiveness increased with concentration and was nearly comparable to that of the standard antibiotic chloramphenicol (28.0 mm) [25]
