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Foods and compounds with documented bitter receptor activation include: Berberine (found in goldenseal and Oregon grape, also a popular supplement for blood sugar support) Green tea catechins (EGCG specifically activates gut T2Rs) Bitter melon (used in Ayurvedic and Chinese medicine for metabolic health) Arugula and dandelion greens (common bitter salad greens) Dark chocolate (85 percent cacao or higher) Incorporating bitter foods into your regular diet provides continuous, low-level GLP-1 stimulation through a pathway entirely separate from the probiotic mechanism

That part of the risk has, I think, lessened, and so I think thats partly why were seeing a decrease, says Magdalena Cerda, an epidemiologist and director of the Center for Opioid Epidemiology and Policy at the NYU Grossman School of Medicine

Arzumanyan ES, Makhro AV, Tyulina OV, Boldyrev AA