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Additionally, when considering cognitive decline caused by aging, dietary intake of caffeine can protect the brain by regulating the Bax/Bcl2 ratio, caspase-3, and PARP-1 levels to reduce oxidative stress, and COX-2, NOS-2, TNF, and IL-1 to further reduce D-galactose-induced neuroinflammation and neurodegeneration (Ullah et al., 2015)

Scientists often refer to it as the "master antioxidant" because of its central role in cellular protection and detoxification

iii) High risk: Three or more criteria rated as unclear or at least two criteria not met

They are also available in dietary supplements, such as fish oil