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In a clinical trial for Wegovy (clinical trial identifier: NCT03693430), patients who received a once weekly injection of Wegovy for two years experienced, on average, a 14.8% reduction in weight compared to 2.4% reduction with placebo
Also, glucagon promotes lipolysis in adipose tissue, providing free fatty acids as an alternative energy source during periods of low glucose availability
44 Reportedly, susceptible loci for EAC are also implicated in ESCC development
These side effects are generally mild to moderate and usually go away within a few weeks
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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