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Serious class-related risks include pancreatitis, gallbladder disease, and dehydration-related acute kidney injury all requiring prompt medical review
33-35 Although single studies evaluating the efficacy of metformin for treatment of hirsutism in patients with PCOS have shown potential benefits, 36-38 meta-analyses showed no significant effects of metformin compared to placebo or oral contraceptives and decreased benefits compared to spironolactone and flutamide
Most patients begin seeing appetite suppression within 12 weeks , with weight loss becoming noticeable by week 4
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