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A supplement strategy should not overlook: Adequate total protein Cysteine-containing foods such as poultry, eggs, dairy, legumes and meat Glycine from protein-rich foods, collagen and connective tissues Selenium from seafood, eggs, meat and selected plant foods Magnesium and B-vitamin adequacy Cruciferous vegetables and other foods that support endogenous antioxidant-response pathways Food does not always replace clinically appropriate supplementation, but poor protein and nutrient intake can undermine the pathway a supplement is intended to support

Fukuyama Y, Miyao M, Ishizu T, Maruyama H

Nat Metab 3:142148

E.AsztalosE.ZinmanB.SimmonsD.et al (2023)