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In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]
Porm, importante dizer que a L-Carnitina no atua como termognico, como o caso da cafena, por exemplo
LR3 IGF-1 promotes cell proliferation, differentiation, and survival, and is widely used as a potent supplement in cell culture systems, tissue engineering, and metabolic research applications
Aging Cell 16 , 1726 (2017)
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