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How It Differs From Standard Titration The FDA-approved prescribing information for Wegovy (semaglutide 2.4 mg) specifies a 16-week dose-escalation schedule: 0.25 mg for 4 weeks, 0.5 mg for 4 weeks, 1.0 mg for 4 weeks, 1.7 mg for 4 weeks, then 2.4 mg as the maintenance dose 2
SURMOUNT-5 head-to-head data sourced from Eli Lilly published results (NEJM, 2025)
It is also possible, but rare, to experience permanent nerve damage and changes to the skins sensation
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