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Perfluorooctane sulfonate mediates GSH degradation leading to oral keratinocytes ferroptosis and mucositis through activation of the ER stress-ATF4-CHAC1 axis

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A randomized controlled trial published in PMC demonstrates that older humans (71.1 years) exhibited significantly lower glutathione levels, impaired mitochondrial fatty-acid oxidation, reduced gait speed and physical function, and higher oxidative stress compared to young controls (25.5 years)

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