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"Comparative Effectiveness of Dual-Agonist Obesity Therapeutics: A Systematic Review and Meta-Analysis." The Lancet Diabetes & Endocrinology, 2024, 12(2): 123-138
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Their effectiveness depends not just on affordability, but on sustained, guided use as part of a broader strategy that includes diet, lifestyle and regular medical care.
Berberine is an unlicensed supplement with limited long-term evidence, whilst metformin is the NICE-recommended first-line treatment with proven safety and efficacy
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