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The most common adverse reactions reported in clinical trials include nausea, vomiting, diarrhea, abdominal pain, and constipation, occurring in more than 5% of patients

Yin TT, et al

The safety profile of semaglutide, in general, has been favorable, but the long-term effects on patients with hypothyroidism remain to be fully elucidated through further research and post-marketing surveillance