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Notably, compensatory crosstalk may limit monotherapy efficacymelanoma cells escaping ferroptosis via FSP1 upregulation may become more dependent on necroptosis suppression, and vice versaunderscoring the rationale for co-targeting multiple pathways to avoid adaptive resistance ( 5 Synergistic therapeutic strategies targeting RCD pathways and immune checkpoint inhibitors Regulated cell death (RCD) pathways, including ferroptosis, pyroptosis, and necroptosis, have emerged as crucial modulators of antitumor immunity, serving as a bridge between tumor cell elimination and immune response activation (123)

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Oxidative stresses, including 4-hydroxy-2-nonenal, nitration, and oxidation, modify posttranslational -synuclein to promote -synuclein oligomerization, which inhibits oxidative stress responses as an antioxidant

The dogs were acclimatized to the housing conditions for at least 7 days prior to the initiation of the experiment