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Analytical workflows commonly combine reversed-phase LC separation, high-resolution mass spectrometry (HRMS), and tandem MS fragmentation to detect low-level impurities and structural modifications

1,3 A 2025 systematic review in the International Journal of Dermatology confirmed that among GLP-1 receptor agonists, semaglutide and tirzepatide showed the highest reported incidence of hair loss, with telogen effluvium and androgenetic alopecia (AGA) identified as the predominant subtypes