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Some lncRNAs have been shown to directly bind chromatin at AR target genes, but whether they have a preference for a specific type of AREs is not clear, nor is the full spectrum of AR target genes chromatin environment that is lncRNA-bound
However, many patients experience the greatest benefits when both are used together, especially when protocols are customized based on age, symptoms, lab results, and health history
2012;227(4):1420-1427.[DOI] 35
The two mechanisms are complementary and their combination produces a documented synergistic effect (Ionescu & Bhatt, Endocrine 2006)
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