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We are interested only in the L form, as this is the one that is found in nature and performs biological functions

While some success with glycolytic inhibitors has been demonstrated in preclinical studies, GBM cells can become resistant and escape via metabolic plasticity and use of alternative substrates such as amino acids, lipids, or glycogen (1416)

For example, in the STEP-1 clinical trial, participants taking semaglutide lost an average of 11.6 pounds of lean body mass compared to just 4 pounds in the placebo group

Because the medication can cause gastrointestinal side effects leading to volume depletion, patients on diuretics or blood pressure medications need careful monitoring to avoid hypotension or acute kidney injury