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Tirzepatide (Mounjaro, Zepbound) is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, though these medications are often collectively referred to as incretin-based therapies
In a randomized placebo-controlled trial in 310 healthy adults under 50 years of age, those given a supplement providing 900 mg EPA plus 360 mg DHA per day for 26 weeks had greater improvements on all but one test of speed and accuracy of memory than those given 900 DHA plus 270 mg EPA or placebo
Trimethylamine is a Lewis base that forms adducts with a variety of Lewis acids
Emerging evidence indicates their potential role in the management of diverse obesity-related comorbidities, including metabolic dysfunction-associated steatotic liver disease, obstructive sleep apnea, polycystic ovary syndrome, neurodegenerative disorders, and even substance use disorders
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