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Absolute contraindications include: Personal or family history of medullary thyroid carcinoma : These medications carry a boxed warning regarding thyroid C-cell tumors based on rodent studies Multiple endocrine neoplasia syndrome type 2 (MEN 2) : Increased risk of medullary thyroid carcinoma Previous serious hypersensitivity reaction : To semaglutide, tirzepatide, or any formulation component Pregnancy considerations: These medications are not recommended during weight management in pregnancy due to limited safety data and potential fetal risks

Management of the underlying cause of the hyperpigmentation is also recommended

Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence

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