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Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism
Once primarily a concern for high-income countries, excess weight and obesity is now widespread across many different regions, income levels and age groups, making it one of the worlds biggest public health concerns
Although predominantly expressed in the adipose tissue 4 , PPAR messenger RNA and immunoreactivity has also been detected in hypothalamic nuclei governing energy balance 5 , and third ventricle adenoviral-mediated overexpression of PPAR decreases food intake in lean and diet-induced obese (DIO) mice 6
Odigwe C et al
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