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While a number of mechanistic studies have found that metformin lowers fasting blood glucose levels by suppressing hepatic glucose production [1,2,3], a substantial body of in vivo data suggest that much of the glucose-lowering action occurs at the level of the gastrointestinal tract, irrespective of its systemic bioavailability [3, 4]

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For example, if you experience significant side effects, they might recommend delaying a dose increase or temporarily reducing your dose

The 5 mg/mL concentration keeps unit counts small and readable (5, 10, 20 units)