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FDA staff reviewers raised these same evidence gaps during the July 2026 advisory committee hearing, specifically citing insufficient data to support efficacy claims for some proposed uses

BPC-157 Effectiveness : (5/5) - Best all-around joint peptide Why it's #1 for joints : Reduces inflammation significantly Promotes tissue healing Works on multiple joint structures Can inject locally near joint Excellent safety profile Mechanism : BPC-157 enhances angiogenesis, modulates inflammatory pathways, stabilizes cellular structures, promotes growth factor expression

Both add important information to ongoing melanocortin receptor and synthetic peptide research