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This effect may be attributed to the appetite-suppressing and weight-reducing effects of GLP-1 RAs, which decrease postprandial lipoprotein secretion and mitigate systemic inflammation
And regulatory approvals already reflect this shift: Wegovy is approved to lower cardiovascular risk, Ozempic slows kidney disease progression, and semaglutide is cleared for metabolic dysfunctionassociated steatohepatitis (MASH) with fibrosis
Holst and colleagues independently characterized the truncated peptide as an insulin-releasing hormone from the distal gut in the same year [3]
Wang M, Chen X, Liu Z, Li Z, Zhu Z, Liu S, et al
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