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Tirzepatide, a newer injectable medication, is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist
That experimental therapy combines GLP-1 and GIP with activation of nuclear hormone receptors known as PPARs targets once used by diabetes drugs like rosiglitazone and pioglitazone
Very little of that process is applied to compounded medications, which is why the FDA recommends them only as a last resort and warns Americans they are not as safe as branded or generic FDA-approved medicines
Other secondary endpoints included a 2-point decrease in NAS with 1-point decrease in two or more NAS components
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