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GLP-1R is present in different brain regions, such as the cerebral cortex, thalamus, hypothalamus, substantia nigra, and cerebellum, having crossed the bloodbrain barrier, influencing processes like appetite control and satiety (15)
Organs like the heart and kidneys are put under constant stress, which, over time, raises the risk for heart failure and early mortality
Patients should not split, estimate or change doses without medical guidance
Another consideration is that both drugs can cause hypoglycemia, especially when used with other diabetes medications
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