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Cellular GSSG accumulation is limited by the fact that cells employ multiple redundant reductive pathways to reduce cytosolic GSSG or to actively export GSSG to the extracellular environment, for example by MRP1 in mammalian cells or to alternative subcellular compartments, for example by Ycf1 in yeast 21,69
Risk oversight in the SkinnyRx program reflects checkout-first enrollment, clinician-controlled prescribing, and pharmacy-controlled dispensing that occurs outside the platform
But our other recommendations are effective in their own rights
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