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Therefore, studies have investigated how CHAC1 is regulated in tumor cells and their microenvironment: Prostate cancer patients frequently develop resistance to docetaxel, a challenge in which cancer-associated fibroblasts (CAFs) have been shown to play a significant role through exosome-mediated signaling (Zhao et al

Immunohistochemical staining showed that the lesions of KO rabbits were characterized by decreased number of macrophages and SMCs: 45% and 90% of lesional macrophages and 87% and 87% of lesional SMCs in hetero- and homozygous KO rabbits compared with WT rabbits (Figure 5B, right)

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