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For patients with T2DM who are planned to initiate GLP-1 RA therapy, particularly those already at risk of early cardiac autonomic neuropathy (e.g., elevated resting heart rate, borderline reduction in heart rate variability), incorporating an SGLT2i (such as dapagliflozin) in advance or as part of the combination regimen may be a strategy associated with better preservation of cardiac autonomic stability
and antiinflammatory and antioxidant responses
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