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At the epigenetic level, chronic methamphetamine and cocaine use are associated with epigenetic changes that induce longer-lasting changes in the synthesis, reuptake, storage, and degradation of dopamine, as well as changes in the sensitivity of receptors within the dopaminergic system [5, 6, 22,23,24, 27, 32, 38, 53, 54]

They act on gamma-aminobutyric acid (GABA), the central nervous systems inhibitory neurotransmitter known to produce a relaxing and calming effect on the brain

Part of the reason is that, while some studies showed strong effects in controlled settings, the evidence was limited (small sample sizes, shortterm)

Many patients begin to notice a reduction in cravings and hunger within the first few weeks, which helps them to maintain a healthy eating plan