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GLP-3 (Reta) Mechanism of Action Acts as an agonist at three receptors the GIP receptor, the GLP-1 receptor, and the glucagon receptor the defining "triple agonist" pharmacology that separates it from single- and dual-incretin compounds

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( a ) A Ligplot+ v2.2 diagram of the N-terminal interacting residues of Ex-4-D-Ala bound to GLP-1R as observed in the conformer 1 model