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Clinical trials have demonstrated that GLP-1 receptor agonists produce substantial reductions in total body weight, with emerging evidence suggesting effects on visceral adipose tissuethe metabolically active fat stored around abdominal organs
Spironolactone's anti-androgenic mechanism can therefore reduce anxiety-driven hyperarousal, one of the most common causes of sleep-onset insomnia
It is worth noting that Ozempic's primary indication remains glycaemic control in type 2 diabetes, with weight loss considered a beneficial secondary effect
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