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Neferine, an alkaloid from lotus seed embryos, exerts antiseizure and neuroprotective effects in a kainic acid-induced seizure model in rats
The FDA approved GLP-1s after testing them in large clinical trials (such as STEP and SURMOUNT ) at specific doses and intervals
The SGLT2i treated cohort showed preservation of eGFR over a 5-year period compared with the GLP-1 RA treated cohort (+3.5 ml/min per 1.73 m 2 vs 7.2 ml/min per 1.73 m 2 , respectively), including patients with established chronic kidney disease (CKD)
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