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The Phase I paradox: intermediate metabolites are often more toxic than the parent compounds

Collingridge GL, Singer W

Oxidation of the Cys residue in the active site of PTPs by ROS abrogates its nucleophilic properties, thereby inhibiting PTP activity (87)

We also quantified metabolites involved in the most proximal stages of the glycolysis pathway, namely glucose-6-phosphate (G6P) and fructose-6-phosphate (F6P) ( Figures 5H, I)