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GLP-1 medications are contraindicated for patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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1hk), these data indicate that the metabolic effects of GLP-1RA/tesaglitazar in vivo also require functional GLP-1R signalling

That said, Wegovy is FDA-approved and widely prescribed for weight loss with excellent clinical responses, while retatrutide is still an investigational drug only available through clinical trials and its long-term safety and tolerability are still being studied