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In drug repositioning it is crucial to understand the disease-drug relationship, for this reason, there are several approaches to address the problem: In silico approaches: in this type of approach, various public databases, clinical trials, and bioinformatic systems are used to identify drug-target interactions ( Cluster approaches tend to find new drug-target or drug-disease relationships (Parisi et al., 2020)

Much of this summary comes from personal experience in treating such patients

[1] [2] Additionally, when used with insulin or sulfonylureas, hypoglycemia may occur, potentially causing adrenergic symptoms including palpitations or chest discomfort