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The peptide demonstrates cytoprotective effects through modulation of cellular stress responses and appears to enhance collagen synthesis and extracellular matrix remodeling, which are fundamental processes in tissue repair and regeneration

Accordingly, adjuvant vitamin B12 has been shown to increase methylation of key genes in inflammatory disorders, resulting in their downregulation

Unlike its parent molecule, Dihexa exhibits enhanced stability and improved bioavailability, allowing it to readily cross the blood-brain barrier and exert its therapeutic effects

Indeed, oxidative stress associated with excessive ROS production and depletion of the antioxidant system is commonly observed in nanomaterial-induced eryptosis [452,453,454,455,456,457]